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However, other studies have suggested that PHGDH inhibition may limit IL-1 production through NAD + accumulation and its downstream sirtuin 1 (SIRT1)/SIRT3 axis, thereby exhibiting an inhibitory effect on inflammatory output (65)
Repeat-dose study in diet-induced obese mice Male DIO mice, maintained on a 60% kcal/fat diet for 15 weeks, were switched to 45% kcal/fat diet for 3 weeks prior to randomization to study groups
Not for human consumption, medical use, or veterinary use
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Includes everything in GLP-2 plus maximum therapeutic dose, weekly medical support and monitoring, advanced metabolic optimization, and personalized wellness integration