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This latter finding has been bolstered by the discovery that thyrotropin-releasing hormone (TRH) gene expression, which has long been known to play a role in the leptin-satiety pathway, is also affected by MC-4R stimulation

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These drugs can reduce calorie intake by between 16-39%, making them a powerful tool to help people living with obesity and overweight

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Their brand-name pens can go much higher, up to roughly $2,000/mo for something like Zepbound or Mounjaro