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Preliminary MRS work(Durieux et al., 2016

Amaral EP, Costa DL, Namasivayam S, Riteau N, Kamenyeva O, Mittereder L, et al

Evidence suggests that these medications exert protective effects through multiple physiological pathways, including modest reductions in systolic blood pressure, improvements in lipid metabolism, attenuation of inflammatory signaling, delayed gastric emptying, and significant weight reduction

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Biological mechanisms explain why lower-dose strategies may still produce metabolic effects