The most robust clinical evidence arguably originates from the large cardiovascular outcomes trials (CVOTs) completed for most GLP-1 RAs, of which the latest showed a significant relative risk reduction (RRR) of 39% (HR) with once-weekly efpeglenatide on HF requiring hospitalisation, corroborating a meta-analysis which found a significant RRR across eight GLP-1 RA CVOTs of 11%
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International union of basic and clinical pharmacology
The Synergistic Effect: Why Combination Therapy May Offer Enhanced Results One of the most interesting developments in perimenopause weight management is how hormone replacement therapy and GLP-1 medications may work together
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