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Phase 2 Results That Led to Phase 3 Retatrutide's Phase 2 trial results, published in the New England Journal of Medicine in June 2023, were strong enough that Eli Lilly fast-tracked it into one of the largest Phase 3 obesity programs ever run

CNS Drugs 39 , 937947 (2025)

Challenges Hindering GLP-1 Nutritional Support Growth Despite the growing demand, the industry faces challenges related to gastrointestinal side effects, which affect up to 50% of GLP-1 users

Last updated June 3, 2026 Editorial policy From Weight Loss Clinics to Addiction Labs The trajectory of GLP-1 receptor agonists has taken a turn that few in the pharmaceutical world predicted

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It can cause side effects such as nausea, vomiting, stomach upset, heartburn, diarrhea, and seizures