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It encompasses a wide range of conditions such as coronary heart disease, hypertension, arrhythmias, heart failure, stroke, and peripheral vascular disease ( 2 MicroRNA: key regulator in cardiovascular pathophysiology 2.1 Overview of miRNA biogenesis and function MicroRNAs (miRNAs) are a class of small non-coding RNAs that play a crucial role in post-transcriptional regulation of gene expression, and since their discovery in 1993, miRNAs have been identified as key regulators of many biological processes, including heart and vascular function ( 2.2 MiRNA dysregulation in cardiovascular disease Cardiovascular disease (CVD) is characterized by dysfunction involving various molecular processes such as inflammation, apoptosis, fibrosis and endothelial dysfunction, all of which are strongly influenced by miRNA expression and regulation

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