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How does the oral GLP-1 work

View Study [3]"Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity" Garvey WT et al., 2025 Finding: The REDEFINE 1 Phase 3 trial showed CagriSema achieved 20.4% weight loss versus 3% with placebo over 68 weeks in 3,417 participants

It is not a replacement for these medications but rather a different approach targeting a distinct metabolic pathway

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And that is the catch: these drugs do not significantly increase metabolic activity, but instead, by slowing gastric emptying and gut motility (literally moving food around your GI), they very effectively control the primitive urge to gorge