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Early studies in obese individuals showed some reductions in body fat mass, but findings are not consistent across trials: In one clinical trial, AOD9604 did not demonstrate statistically significant weight loss compared to placebo, suggesting its fat-burning effects may be modest without lifestyle intervention (summary of trials)

The high demand and high cost of these medications create incentives for inappropriate prescribing, prescription diversion, or attempts to obtain medication without proper clinical evaluation

Total time from first Phase 3 enrollment to approval: roughly 3 years

Maximum Recovery

Current clinical evidence suggests that GLP-1 receptor agonists do not directly impair fertility, though hormonal changes during rapid weight loss may temporarily affect menstrual cycles

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