Clinical trials tested doses ranging from 250mcg to 1mg daily, with most protocols settling around 300-500mcg for optimal fat metabolism support
Any protective effect likely comes from general cellular resilience rather than direct anti-androgenic action
Reducing application frequency or concentration can minimize irritation for sensitive individuals
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However, the uncertainty with this is whether it presents a pre-vitamin B12 deficiency or PA, where individuals are not yet symptomatic or are symptomatic but have a serum B12 value within the normal reference ranges
doi: 10.3389/fphar.2021.627533 Received 09 November 2020 Accepted 03 February 2021 Published 29 June 2021 Volume 12 - 2021 Edited by Gabor Varga, Semmelweis University, Hungary Reviewed by Alexandra Mik, University of Pcs, Hungary Zoltn S