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To investigate how metformin exerted its antioxidant effects, we first examined the expression of Nrf2 and its downstream regulatory protein HO-1 in the chondrocytes exposed to H 2 O 2 , with or without metformin treatment
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Sustained elevation of pulsatile growth hormone (GH) secretion and insulin-like growth factor I (IGF-I), IGF-binding protein 3 (IGFBP-3) in combination GHRH and GHRP-6
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Elevated insulin from food blunts growth hormone release
