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Fortunately, the toxicity of paracetamol overdose is effectively attenuated by administration of the antidote acetylcysteine (NAC), at least if administered within 8 h of the overdose [3]

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Detoxification Reactions Because glutathione supports the liver, some people experience a "herxheimer" or detox reaction, which can feel like a mild headache or slight fatigue as the body begins to process stored toxins more actively