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The comparison with the crystal structure of GPX4 (PDB 6HN3) revealed that a modelated GpoA display orthologous residues that could conform the catalytic site of tis enzyme, including Gln 70 , Trp 124 and Asn 125 , but Cys 36 in the place of Sec 46 (Fig
It is thought to influence the hypothalamic-pituitary-adrenal (HPA) axis, aiding in stress response regulation by stabilizing blood pressure and reducing stress hormones like cortisol
PMID: 1689548
doi: 10.1371/journal.pone.0173004 96 OuwerkerkJ
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