Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist with FDA approvals for two distinct indications: Mounjaro for type 2 diabetes management and Zepbound for chronic weight management in adults with BMI 30 kg/m or 27 kg/m with at least one weight-related comorbidity
It hasnt been denatured yet
Common side effects include nausea, vomiting, diarrhoea, and constipation consistent with the known GLP-1 receptor agonist class profile
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This glucose-dependent mechanism is what makes GLP-1 agonists safer than older diabetes drugs that could cause dangerous hypoglycemia
This article examines how GLP-1 medications work, the clinical evidence supporting their use, eligibility criteria, and important safety considerations for women with PCOS