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The SUSTAIN-6 CVOT [67], performed in 3,297 patients with T2DM and ASCVD/CKD, has shown that compared to placebo, semaglutide was associated with increased retinopathy complications (3.0% versus 1.8%
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They are registered with the FDA, inspected by the FDA, and must follow current good manufacturing practices (cGMP)
[see Clinical Pharmacology (12.3)]
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