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The resulting PBPK model for metformin in humans includes 21 tissues and body fluids compartments and can simulate metformin concentration in the stomach, small intestine, liver, kidney, heart, skeletal muscle adipose, and brain depending on the body weight, dose, and administration regimen
These findings make BCAA pathway markers attractive for myocardial hypertrophy, especially when hypertrophy coexists with obesity, diabetes, hypertension, or kidney disease
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About this article Cite this article Abdel-dayem, S.I.A., Fahim, S.A., El-Dessouki, A.M