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In this group, the hepatic secretion of biliary bile acids and the solubilization of cholesterol in bile are greatly reduced, another factor associated to supersaturated bile [7]

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Ghafouri-Fard S, Shirvani-Farsani Z, Hussen BM, Taheri M, Samsami M

A higher water amount means a weaker concentration

In humans the effect is much less dramatic, and alcohol consumption causes a transient two-fold induction of CYP-2E1 ([43, 46])