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The Red zone is the outer perimeter and has an adequate blood supply to facilitate healing

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The two engineered cysteine residues per heavy chain (S239C and S442C) enable site-specific conjugation of AZ13599185 to the antibody via a maleimidocaproyl linker, resulting in a biparatopic ADC with a DAR of 4

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Peptide sequences that target cytosolic proteins for lysosomal proteolysis

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