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In a rat ischemic wound model, topical tripeptide-copper complex reduced wound area more than vehicle and was associated with lower TNF-alpha and MMP-2 and MMP-9 concentrations at measured time points 16
In a rat model of respiratory colonization of C
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The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity
