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Recent preclinical andclinical studies have demonstrated the significant potential of GLP-1RAs in slowing the progression of neurodegenerative diseases [16, 17]
Recent studies, such as the SUSTAIN trial, have indicated promising cardiovascular benefits associated with Semaglutide use
This prevents overlapping doses and reduces the likelihood of dose-dependent adverse effects, particularly gastrointestinal symptoms which are the most common reason for treatment discontinuation
The authors hypothesized that early life adversity may alter oral microbiome composition, which can shift to gut via saliva, potentially creating a pro-inflammatory state that increases vulnerability to PTSD following subsequent trauma exposure (Malan-Muller et al., 2022)
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Phase Dual escalation 1 Weeks 13-16 Retatrutide 8 mg/week Cagrilintide 0.5 mg/week Notes GI effects often peak here
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