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Kudlaty E, Perez M, Stein BL, Bochner BS, Kuang FL

Gene expression profiling of photoaged skin treated with GHK-Cu reveals normalization of over 70% of UV-dysregulated genes, with particularly strong effects on genes involved in matrix synthesis, inflammatory responses, and oxidative stress defense

It activates genes involved in DNA repair, stress response, matrix remodeling and antioxidant defense, while suppressing genes associated with inflammation, fibrosis and tissue destruction

Gradual titration is essential: Starting low (around 0.25 mg weekly) and stepping up slowly markedly lowers the odds of early gastrointestinal effects [4]

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