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Once semaglutide became widely used, post-marketing surveillance systems like the FDA Adverse Event Reporting System (FAERS) began collecting real-world data

The projected impact is significant, with the program expecting to generate approximately $30 million in annual net savings on GLP-1 medications and including performance guarantees tied to treatment outcomes

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The most common include nausea, vomiting, diarrhea, constipation, and stomach discomfort, which often improve over time