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FIGURE 2 3 Redox dysregulation in disease states 3.1 GSH in peripheral immune cell infiltration Several studies indicate that neuroinflammatory changes associated with neurodegeneration compromise the BBB or its function by disrupting transport systems, facilitating the infiltration of immune cells, and influencing the BBBs role as a signaling interface

Protein expression was quantified by using QuPath-0.4.3 analysis tool

The dose-response data broke down as follows: 1mg dose: 8.7% average weight loss at 48 weeks 4mg dose: 15.2% average weight loss at 48 weeks 8mg dose: 21.1% average weight loss at 48 weeks 12mg dose: 24.2% average weight loss at 48 weeks Placebo: 2.1% average weight loss at 48 weeks The week-by-week progression told an equally compelling story

Meanwhile, following a prolonged period of erastin treatment, VDAC2/3 failed to be detected in the cells and such reduced expression resulted in erastin resistance (Yagoda et al., 2007)

Trial registration: clinicaltrials.gov: NCT03071666

It is advised to have it with a glass of water or mixed with a liquid