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That follow-up trial, involving 536 obese adults over 24 weeks, failed to meet its primary efficacy endpoint, meaning the fat-loss effect seen at the smaller scale did not hold up in the pivotal study

In addition, other studies have found that various iron inducers, such as Erastin, and RSL3, strongly activate NUPR1, supporting its protective effect on iron [86]

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This approach effectively lowers inflammatory factor expression levels following PEID, alleviates postoperative low back and leg pain symptoms, reduces hospital stay duration, and accelerates recovery