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Specifically, at concentrations of 100 nM and 1,000 nM, GLP-1R agonist 2 significantly enhances 10 mM glucose-induced insulin secretion, similar to GLP-1, and this effect is abolished in islets from GLP-1 receptor knockout mice [2]

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During exposure to experimental conditions, cells were maintained in DMEM/F-12 with 1% FBS (GBM and iNHA cells) or DMEM 1%FBS (b.End3)