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Both endothelial cells and pericytes contribute to generate components of the basement membrane, which is a vital component of the BBB, providing structural support, cell anchoring, regulate immune cells, and signaling transduction [1, 29, 30]

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By influencing hormonal signaling and aggregating in prostate tissue, they assist in regulating cell proliferation, inhibiting inflammation, and promoting apoptosis, so contributing to a potential chemopreventive impact against PCa

Second, the multiple meta-analyses and systematic reviews cited in this article may carry a risk of accumulated type I errors (240)

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