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These drugs exert their effects by inhibiting the thiazide-sensitive Na + /Cl cotransporter identified as NCC (also identified as NCCT: encoded by the SLC12A3 gene)

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faecalis (20), identifying that the promoter of the operon arc (EF0104, EF0105, and EF0106) contains a DNA binding site for the regulator ArgR, which is consistent with the transcriptional changes of these genes in the mutant under iron exposure

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