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However, metformin administration failed to rescue paw withdrawal thresholds or pain sensitivity in Nrf2 KO mice, unlike the protective effects observed in MIA-induced WT OA mice (Fig

Despite widespread anecdotal claimssome describing these agents in near-miraculous termsthe extent to which peptides deliver meaningful clinical benefit remains uncertain

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However, the main problems of marketed biologics/drugs are nonresponses and partial responses as well as the occurrence of adverse effects like stomatitis, exanthema, and diarrhea

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