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5 These broad potential indications, coupled with payer concerns about affordability, access and long-term cost-effectiveness, make it clear that GLP-1 obesity treatments are more than a passing trend and they demand robust evidence and longer term real-world monitoring
These factors may include high BMI at the start of the therapy, adherence to nutritional guidelines, presence or absence of exercise and the type of exercise used, and more
This may translate to 2-4 kg of fat loss over a 12-16 week protocol, with significant individual variation based on adherence and individual factors
It has also been shown to positively impact exercise recovery and muscle fatigue
Based on the results of clinical data, empagliflozin and dapagliflozin are now recommended for the treatment of HFpEF, as well as for HFrEF also in the absence of diabetes (McDonagh et al., 2021
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