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No events of severe hypoglycaemia requiring hospitalization were observed (Table 4)
REDEFINE 2 reported that the prevalence of nausea, vomiting and diarrhoea was highest during the dose-escalation phase and settled afterwards
Gclc fl/fl mice were described previously 127 and were crossed to Mb1-Cre + expressing mice 46 to obtain the Gclc fl/fl Mb1-cre strain
Gamradt S, Hasselmann H, Taenzer A, Brasanac J, Stiglbauer V, Sattler A, et al
Zhang et al., 2018, 2019