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Using tissue from donors, the team observed that cells in the nucleus pulposus, a jelly-like structure at the center of intervertebral discs, had a lower amount of this peptide receptor when degeneration increased

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Metformin exerted a neuroprotective effect through the inhibition of apoptosis and activation of autophagy in mice with experimental spinal cord injury (Sarge and Park-Sarge 2009)

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