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Pemetrexed disodium is an investigational, novel, multitargeted antifolate with inhibitory activity against multiple enzymes involved in non-small-cell lung cancer (NSCLC), mesothelioma, and breast, pancreas, colorectal, gastric, cervical, and head and neck cancers, said lead investigator Paul Bunn, Jr., MD, University of Colorado Health Sciences Center, Denver

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