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The most common adverse reactions reported in patients treated with semaglutide include nausea, vomiting, diarrhea, abdominal pain, and constipation.[5-7] Semaglutide may also increase the risk of pancreatitis, acute gallbladder disease, hypersensitivity reactions, acute kidney injury, and thyroid C-cell tumors.[5-7] Whether semaglutide is safe in people with pancreatitis remains unclear.[5-7] It is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).[5-7] How Long Will Semaglutide Weight Loss Results Last

GLP-1 effects can take time to manifest fully, and premature dose escalation increases side effect risk without necessarily improving outcomes

Muscle maintains metabolism

NHS Obesity Treatment Overview 6

GLP-1 and GIP c

doi: 10.1073/pnas.2116125118 25 GuilloteauPMartinLEeckhautVDucatelleRZabielskiRVan ImmerseelF