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In preclinical models, the selective inhibition of CD45 phosphatase with compound 211 significantly delayed tumor growth and reduced metastasis without impairing the function or number of resting T cells [156]
This is a reversible, competitive inhibition mechanism that does not carry the cytotoxic risk of hydroquinone-based inhibitors
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Transport of ALCAR across cell membranes, including the blood-brain barrier, is primarily mediated by the organic cation/carnitine transporter 2 (OCTN2, encoded by SLC22A5), a sodium-dependent transporter expressed on the luminal side of endothelial cells [5]
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