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Ces mcanismes, dcrits ds 2005 par Villarama et Maibach et confirms par des travaux in vitro ultrieurs, sont biochimiquement cohrents

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Research shows that taking 3 g per day for six weeks can saturate keratinocytes in the skin, but taking more does not increase levels and may cause diarrhea

The gradual titration protocol helped minimize these effects compared to rapid dose increases

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