The frequency of drug-related hepatic injuries, including from NSAIDs, was found to be different in Spain and France suggesting that several factors besides the NSAIDs, such as drug use patterns and/or genetic and environmental factors, may be important 36
Perricone, C., De Carolis, C
If left untreated, these changes can progress to liver fibrosis, cirrhosis, and ultimately liver failure
Statistical significance was determined by multiple two-tailed unpaired t-tests with correction for multiple comparisons using the Holmdk method
16 Interestingly, one patient had some abnormal changes in the elastic fibers and another patient had some excess of elastic fibers
doi: 10.1530/eje.0.1390552