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Doubling up on doses to make up for a missed dose is not recommended

Orlistat has important drug interactions, including with ciclosporin (avoid or monitor closely if unavoidable), warfarin (monitor INR), levothyroxine (separate by at least 4 hours and monitor TSH), antiepileptics (monitor for changes in seizure frequency), and acarbose (avoid combination)

Key patient factors to take into consideration include: 1) comorbidities, such as atherosclerotic cardiovascular disease (ASCVD), chronic kidney disease (CKD), and heart failure