Wegovy is not recommended in severe hepatic impairment and should be used cautiously in mild to moderate impairment Have type 2 diabetes with diabetic retinopathy, which may need closer monitoring Have gastroparesis (delayed stomach emptying)
doi:10.1016/j.ejphar.2024.177095 Li W, Zhou Q, Cong Z, et al
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Cytosolic NADPH can amplify insulin secretion in a GRX1-dependent manner [7, 8], for example through redox-regulated de-SUMOylating of exocytotic proteins by sentrin/small ubiquitin-like modifier specific peptidase 1 [35]