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For patients without neurological involvement , hydroxocobalamin 1 mg is administered intramuscularly three times a week for 2 weeks, followed by maintenance injections every three months for life (if due to pernicious anaemia or other non-dietary cause)

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251,252 Elevated proteasomal activity is frequently observed in colorectal cancer (CRC), where deregulation of specific 20S proteasome subunits has been linked to carcinogenesis

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