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Doctors are skeptical
IV administration achieves near-100% bioavailability and shows 4045% reduction in hangover severity when given within 46 hours of drinking
Studies have indicated that berberine might increase endogenous GLP-1 secretion from intestinal L-cells or affect GLP-1 degradation, but this is fundamentally different from directly activating GLP-1 receptors
Some clinical observations suggest that while the dual action can lead to more significant weight loss, it may also lead to a more pronounced feeling of tiredness in the initial stages compared to GLP-1 alone
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Itheima, "Psilocybe cubensis indoor," Wikimedia Commons
