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10.1126/scitranslmed.3007218 38 FinanB.YangB.OttawayN.SmileyD

Semaglutide reduces your calorie intake automatically, but the *quality* of those calories matters for energy, muscle preservation, and metabolic health

Preclinical research indicates that intra-articular (IA) liraglutide attenuates synovial inflammation, decreases catabolic markers such as ADAMTS-5, and limits cartilage and bone damage across three experimental OA models, including MIA (mono-iodo-acetate), DMM (destabilization of the medial meniscus), and collagenase II-induced OA

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118 Over-expression of liver SREBP-1c has been described in several IR models of including IRS2 knockout, 119 lipodystrophic and ob/ob mice

In 2021, the FDA approved Wegovy (a higher-dose version of semaglutide) for chronic weight management in people with obesity