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922 In AKT-hyperactivated cancer cells, AKT directly phosphorylates the Ser343 site of TRPML1, inhibits the K552 ubiquitination degradation of TRPML1, and promotes the binding of TRPML1 to ARL8B, leading to lysosomal exocytosis

Common GLP-1 side effects include nausea, vomiting, constipation, and abdominal discomfort, particularly in the first 24 weeks of treatment

More and more people without diabetes are using this drug safely and effectively, and doctors are beginning to recommend it more often for this purpose

Zhang Z, Xie Y, Yi Q et al (2025) PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation