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Polycyclic aromatic hydrocarbons (PAHs) found in cigarette smoke, for example, have been shown to decrease the activity of P450 enzymes, leading to a decrease in SAMe production and impaired DNA methylation

These include: Metformin (used for diabetes or PCOS) Proton Pump Inhibitors (used for acid reflux or GERD) H2 Blockers Birth control pills Certain antibiotics If youre taking these medications long-term, particularly in combination, regular B12 injections might be beneficial

These include the binding of a metal to a given AT, leading to decreased production of RS or the ability to scavenge RS

APX, which is the first enzyme of the cycle, detoxifies H 2 O 2 by bringing about the peroxidation of AsA and yielding monodehydroascorbate radical (MDHA)

Meanwhile, in RAAS, ACE's conversion of angiotensin I to angiotensin II, which has a potent vasoconstrictor impact, may cause the adrenal cortex to generate more aldosterone, both of which raise blood pressure

Whats happening: Collagen remodeling is accelerating, the extracellular matrix is being restructured with new collagen fibers