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However, a meta-analysis summarising the data from three human studies in Asia on allulose effects and glycemic control concluded that allulose failed to show any beneficial actions (Reference Noronha, Braunstein and Blanco Mejia39)

West et al., 2021)

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There are many agents with a well known depigmenting effect like pycnogenol, orchid extract, marine algae extract, cinnamic acid, soy, aloesin, Boswellia , hydroquinone, glycolic acid, arbutin, kojic acid, ascorbate, tocopherol, niacinamide, etc

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Clinical trials showed average weight loss of 15%17%, roughly double that of previous drugs