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Studies have shown that saliva transplantation from patients with periodontitis can induce upregulation of IL-1 and IL-6 in the colon of recipient mice, while the immunosuppressive IL-10 is downregulated, suggesting that saliva-derived microbiota may induce gut microbiota dysbiosis and low-grade intestinal inflammation through immune imbalance (Bao et al., 2022)
Hontecilla-Prieto L, Garca-Domnguez DJ, Berlanga-Gil C, et al
The pattern is often patchy rather than uniform, and it tends to flare most in areas where you applied the product most heavily
Sheweita SA, Tilmisany AK
The micro-spicules in the formula enhance the absorption of active ingredients into skin
Standard protocols include 4-week breaks after 12-16 weeks of use
