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In addition, previous studies have found BBB disruption due to MMP-9 activation in patients and animal models (264), and the decrease levels of tight junction protein and adhesions protein in spinal cord (265)

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The second hypothesis also relies on the GSH:GSSG ratio, stating that because there is an excess of GSH, ozone exposure does not change the absolute amount of glutathione, just the percentage in the oxidized form

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