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10.1161/01.ATV.0000242794.65541.02 Arterioscler Thromb Vasc Biol

Complement modulates the function of the ubiquitin-proteasome system and endoplasmic reticulum-associated degradation in glomerular epithelial cells

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ASK1 goes on to bind to TRAF2, which in turn activates downstream-signaling cascades, including the MKK3/4/6p38 and MKK4/7JNK signaling pathways 36,37 (Figure 4)