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The FDA has additionally reported that some semaglutide products sold by compounders may be salt forms such as semaglutide sodium or semaglutide acetate, which the agency describes as different active ingredients than those used in the approved drugs, with unknown comparability of chemical and pharmacologic properties
Light exposure Semaglutide is light-sensitive
Safety in patients with existing mild-moderate liver disease Correlation between weight loss and estimated liver fat reduction TRIUMPH-2 (Ongoing, Expected 2026) Primary Endpoints: Weight loss in diabetic patients HbA1c reduction Secondary Endpoints (Liver): Liver enzymes Metabolic markers Diabetic Population Note: Higher prevalence of MASLD/NASH (~40-50%), so liver benefits particularly important in this group
The broader Canadian patent picture Benefits and Pensions Monitor reported that the core patent for semaglutide lapsed in Canada after missed maintenance fee payments and the expiry of data exclusivity on January 4
The details can vary by medication, procedure, health history, and individual treatment plan
