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If gastrointestinal symptoms are contributing to sleep problems, ensuring adequate time (2-3 hours) between your last meal and bedtime may reduce nocturnal discomfort

One limitation is that medications with substantially different adverse event profiles may generate ratios that do not entirely capture their true visual impairment risk

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When the body metabolizes fat rapidly, cholesterol concentrations in bile increase, creating conditions favorable for stone formation

The gastrointestinal effects are generally transient, improving within 4-8 weeks as tolerance develops