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25,57 In vitro studies have shown that chetomin inhibits HIF-1 to significantly reduce hypoxia-induced radioresistance in MG-63 cells 24 (Table 1)

This was related to EGFR inhibition and VEGF pathway activation 25 (Figure 2 and Table 1)

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Phenotype definitions Using the information derived from the surveys, we defined phenotypes that aimed to capture aspects of drug efficacy and side effects

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