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Guven DC, Erul E, Kaygusuz Y, Akagunduz B, Kilickap S, De Luca R, et al
Due to its rapid enzymatic degradation, the physiological half-life of GLP-1 is short
It is encoded inside mitochondrial DNA and activates AMPK, the cell's master energy sensor, pushing tissue toward burning fuel rather than storing it
This is particularly concerning for a complex peptide, of which semaglutide is one
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